I too have noticed this but even more infuriating, sometimes I'll click a number to prep one of my skills and then click a demigod and it wont cast for some reason -- even when I've got all the mana in the world. It might be bugging because they're out of my immediate range? If that's the case, it should always attempt to move me within range, which usually it does.
It's very strange but it's been noted by me as well as a few other players before -- specifically with sedna's heal but not limited to that at all.
There's definitely some targeting bugs still lingering in the game that are absolutely infuriating. They've lost me kills or gotten me/my teammates killed before.