No problems with AVG.  Plus AVG has a custom ignore/exception list.  And it's free.

Norton and Mcafee suck big time.

Yeah, Norton and McAfee can suck my big male genitals. AVG is free, but I find it to be more of a resource hog than BitDefender. Not free, but very convenient and I have had a great experience with it. Game/Laptop Mode works very nicely with gamers, and the Ignore/Exceptions list is also very handy.

Well, there really isn't anything you can do if someone is too stupid to turn off their anti-virus.

I subscribe to McAfee, but I'm on the verge of uninstalling it and looking for something else.  It's the most intrusive thing I've ever had anything to do with.   I sometimes play webgames at www.popcap.com and McAfee has a heart attack when I do.  You have to install something in your browser (don't remember what) but as soon as I do it, McAfee simply shuts down IE without warning, regardless of the fact that the site tells you up front what they're doing and to click a button to confirm it.  I have to shut all of the protections off to access the site.

Annoying.

Actually... use Avast. It's also free and has far more features than AVG has. You can find it on Download.com. I use to use AVG but stopped because of the false positives and resource hogging, atm, I think Avast is the best. Try it out.

i have the latest norton and it doesn't effect demigod but it is a major  powerdrain

I guess people in the forums responding to this migt be in the larger % of users who know not to run anti virus while playing demigod, probably a biased question on the foums.