About 99% of my clicks register. To be exact - almost all of them. But sometimes I can't use Unclean Beast's spit, it simply sits and does nothing till I make a move order. I use spit 10 times and nothing happens, make it move, use spit again and it works. Is this the targeting bug, which is supposed to be fixed? It started after re-installing the game. It is supposed to be fixed in a previous update so I'm afraid the game only installed the latest update but not cumulative one.
Also, after re-installing the game and applying latest patch, I started experiencing "fixed" issue - my DG gets forgetful as soon as I use any ability, for example using wand of speed makes it stop moving, same as any ability used on another demigod makes my demigod target the nearest enemy or just stop right after using ability. History says it was "fixed" in previous patch, same as sound issue (the UB keeps roaring after I leave character selection screen).
Reinstall the game and see for yourself! 
I'd be happy to help anyone who can fix these issues. I've already made a post on Stardock forum and sent them a letter on e-mail. I hope to either get a cumulative update or at least get ability to download and install all patches since the release, one after another in the order they appeared so that "fixed" bugs get fixed for real.