The trick is you need to alter your build path depending on what you are up against. I don't have a static build for most demigods or always pick the same demigod for each match.
In the lobby I look at my opposition and choose the demigod that will work best against my enemies and work will with my teammates. Then I usually pick the same first 1-4 level skills but after that it's all dependent on what my opposition does.
Sedna for instance: If I'm going up against a TB, Erebus, Rook, or Sedna I'll get at least 1pt in silence. TB and Erebus beign silenced is a big deal because fireball, ring of fire, fire / ice nova, charm are easily interuptible and then they are silenced for 3 seconds which usually makes them second guess their strat and run away. Rook, if he's hammer slam or if he's going to structure transfer it's useful but you can generally use pounce too.
I used silence last night to great effect because I was up against a TB and Erebus. I'm sure it pissed them off a bunch of times.