there is a cap. I can't find the post where frogboy confirmed it. I believe it is -55% off the top of my head.
That doesn't seem correct, I've been hit by both the Mark and the Mines slow at the same time and even with Wand of Speed active I was barely moving (no kidding, I was CRAWLING across the screen). It was way over the top.
Of course all of this talk of if the Mark is worth taking or not is a complete derail from the OP. The question is what can be done about it when you have to face it? I play a lot of TB and all I can say is there is almost nothing you can do. Being forced to take a specific favor item just to survive against a particular skill set up (which you won't be sure your opponent is even going to do) is ridiculous (and it's not even a guarantee that it will end up helping you that much).
There is also another favor item that gives a cap to the amount of speed reduction that can affect you, but that is a crap item.
My only option has been to engage the Reg with this set up in a 2v1 situation only, but of course the opposing Reg can just hang near another teammate at all times so...
Koz