I'm surprised you people rebind keys, but don't make Z, X, and C useful keys. Do you really need to be able to bring up the character screen instantly?
The idea of rebinding is to put things closer to your default hand position during a game, ideally you shouldn't be moving from that position in the middle of an actual fight, where milliseconds of reaction time matter. In my case it's WASD, camera controls are too important in a game where you can zoom out to infinity, and Rook is so goddamned big you have to adjust the camera to his location.
So anyway, my point. I has one. When you're binding, think about what you need to hit that matters from a reaction time perspective. For me it's items, skills, and demigod selection, so items go on z, x, and c. Skills remain on 1, 2, 3, and 4 (although that's still more awkward than I'd like, Q, and E are usually prime real estate, but I'm too used to using them to rotate camera now.) Demigod selection/minion select is bound to shift+1, 2, and 3. this puts everything I'd need to hit in the middle of a battle within easy reach of WASD, so there's no hand shifting required.
