That's not exactly true. You can give them something to compensate for the lack of interrupt AS LONG AS IT ACTUALLY COMPENSATES.
Well maybe, but I don't really see anything out there that CAN compensate for not having any ability to stop a tp or a lock, especially when a few Dgs (TB, LE and Sed) each have a stun AND an interrupt.
The only one who does okay without one is Occ, because late game, when interrupts really start to matter, he can often kill you in that 2 seconds it takes to tp or lock.
Queen is strong early, and Reg can be, but when it comes to the portal game, they can do very little on their own, except keep your own portals locked. But your team is at a huge disadvantage if one of your Dgs can't properly protect a portal, and all three of theirs can.
It's not a coincidence that the top 5 demigods (Oak, LE, UB, Rook and Sed) all have great stuns/ interrupts. It is not the only thing that makes them powerful, but it is a prerequisite.