Has anyone else noticed that sometimes clicking on buttons nothing happens?

I've noticed a few times I have to double click on the select icons to select my minions/demigod.

More annoyingly I was playing a lan skirmish game and it would not register me clicking on certain skill icons.  I was trying to select the 3rd QoT health absorb skill and it simply wouldn't register, sometimes i would spam click on it for awhile and it worked, other times I gave up and selected something else.  This happened on several level ups to the same skill.

I played around 10 SP games before with QoT and saw no issues, so either it is some transient issue or maybe it was linked to the LAN skirmish.