I am having this same problem, extremely frustrating. I've tried playing with the settings but to no avail. You CANNOT EVEN CTRL-ALT-DELETE out of the game. You have to hard reset your PC everytime you try again. Makes me want to return the game as apposed to tell all my friends to buy it (which I usually do when finding a good game).
Hope this is fixed soon, bad news.
EVGA 680i SLI Motherbaord, Core 2 Duo E2600, GTX 260 Core 216 superclocked in SLI config, 2GB Ram, Intel X25-M SSD HD, XP SP3 Pro 32-bit, completely updated Nvidia drivers on chipset and video card.