Queen of Thorns Shambler Mulching
I know it's a good strategy; stay in one lane, shield and AA people away, and mulch in another to get all the EXP/Gold. But I had a match recently where the enemy QoT simply stayed at the health crystal and sent a constant wave of shamblers to where our creeps met (on Cataract) and blew all of them up, every time. She was overlevelled, her teammates were somewhat underlevelled, but without our creeps the enemies had a big creepy meatshield to kill the towers (well, it didn't help that our Reg was AFK half the time and throwing mines anywhere he could the other half, and our rook was the kind of dumb rook who runs away while being hit in a 6 tower farm). So in the end, we lost.
But honestly, does that really make any sense? The QoT can stand at her mana crystal the entire game and out-level two demigods who were actually out doing something. It's like Regulus mana-crystal sniping, except it works well. The QoT only ever left early game, before she got mulch, and occasionally to capture flags (she had a swift anklet as a favor item, and with shield she was unkillable as long as she ran).