When I play with dual-monitors enabled, I can scroll past the edge my game screen. This often causes me to click offscreen, which then in turn causes my game to minimize. It's really irritating. My temporary fix has been to disable my 2nd monitor while I play Demigod. But what's even more irritating, is not having my 2nd monitor on while I play (I don't like missing IMs).
edit: Oh yeah... HELP, PLEASE! 