So, first sorry, new to the game/beta and still don't know the right name of the things (and my english is not really good).
Don't know if it's related but after Rooks doing his hammer smash, with a lot of thingies on the screen and me trying to blast him with my gun (the skill where he put a knee on the ground and take the time to aim to launch a big blast). The game froze for a couple of seconds than disco party all over the screen. I can continue to play like that but everything is so messy that I can't figure what I'm doing...
Running the game at 1400x900; everything at max except V-sync and anti aliasing, the glitch came after 5 minutes in game (maybe a bit less)
So a screenie of the party : http://img237.imageshack.us/my.php?image=discofk0.jpg
And the dxdiag : http://www.mediafire.com/?mgdiydtdd8c
So be nice, it's my first try to report bugs for a game, and I'm not really sure if it can helps 